Nicotinamide Riboside

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Nicotinamide Riboside (NR) is a form of vitamin B3 that acts as a building block of NAD+ (nicotinamide adenine dinucleotide). NAD+ is an important molecule that is involved in cellular energy production (ATP) and DNA repair in experimental models.

Researchers have observed that NR may increase the levels of NAD+ in preclinical models. Preliminary studies have indicated that every cell requires NAD+ to produce energy in research models.

Chemical Properties

PubChem CID	439924
Molecular Weight	255.25 g/mol
Synonyms	nicotinamide riboside 1341-23-7 nicotinamide ribose nicotinamide-beta-riboside ribosylnicotinamide
Molecular Formula	C11H15N2O5
IUPAC	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide
CAS	1341-23-7

Working Mechanism of Nicotinamide Riboside

Nicotinamide Riboside (NR) may work by increasing the NAD+ levels in research models. NAD+ (Nicotinamide Adenine Dinucleotide) levels may decline in research models over a certain period of time.

When it enters the experimental models, NR converts into nicotinamide mononucleotide (NMN) by riboside kinases (NRKs). After that, it changes into NAD+ through a series of enzymatic reactions.

NAD+ is one of the essential molecules. Researchers have observed that NAD+ helps with cellular energy production.

Furthermore, it has been shown to activate proteins like sirtuins and PARPs. The aforementioned proteins are involved in DNA repair, stress resistance, and cellular longevity in research models.

Potential Benefits and Side Effects of Nicotinamide Riboside

There is very limited research on NR. However, so far, the research has indicated the following benefits and side effects of NR in different experimental models under controlled lab settings.

NR| Potential Benefits

May improve cardiovascular health in research models
It may help with anti-aging in preclinical models.
May support neurodegenerative health in experimental models
May help with inflammation in research models

NR| Side Effects

May cause nausea in research models
Hot flashes are observed in research models
May cause abdominal pain in research subjects

Disclaimer

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