Gonadorelin
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Gonadorelin refers to a synthetic decapeptide that functions as an analog of naturally occurring gonadotropin-releasing hormone (GnRH). Endogenous GnRH is produced by the hypothalamus. Plus, it plays a central role in regulating the hypothalamic-pituitary-gonadal (HPG) axis.
As a man-made peptide, Gonadorelin mimics the biological activity of natural GnRH. It does this by stimulating the anterior pituitary gland to release key reproductive hormones, including:
- Luteinizing hormone (LH)
- Follicle-stimulating hormone (FSH)
Because it is a synthetic analog, Gonadorelin is structurally designed to replicate the signaling activity of endogenous GnRH while being distinguishable from the naturally produced hormone.
Chemical and Molecular Properties
| PubChem CID | 638793 |
| Molecular Formula | C55N75N17O13 |
| Molecular Weight | 1182.31g/mol |
| Synonyms | Gonadorelina
GnRH-I 33515-09-2 Gonadorelinum |
| IUPAC | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| CAS | 33515-09-02 |
| Labeling | Research Use Only (RUO), not for human or animal consumption. |
| Chemical Structure Depiction | |
| Purity | 99% Purity |
| Classification | Research Use Only (RUO) |
| Storage Temperature | Store below 25°C |
| Solubility | Water, DMSO (research-grade solvents) |
| Safety | Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible |
Mechanism of Action
Gonadorelin was observed to influence GnRH receptors. These are located in the anterior pituitary gland. Upon receptor binding, it stimulates the secretion of gonadotropins. These are primarily LH and FSH.
- LH (Luteinizing Hormone): Involved in testosterone production in males and ovulation in females.
- FSH (Follicle-Stimulating Hormone): Supports spermatogenesis in males and follicular development in females.
Research suggests that Gonadorelin may promote LH release more prominently under certain physiological conditions. However, both LH and FSH secretion are influenced through receptor activation.
Its receptor-mediated activity makes it a compound of interest in endocrine signaling research and pituitary function studies.
Potential Research Applications
In clinical and investigational settings, Gonadorelin has been explored for its role in evaluating and stimulating reproductive hormone pathways.
Research areas of interest include:
- Assessment of pituitary gland function
- Evaluation of LH and FSH secretion dynamics
- Investigation of hypogonadotropic hypogonadism
- Study of delayed puberty mechanisms
- Controlled induction of ovulatory response in specific clinical contexts
- Research into male reproductive hormone signaling and spermatogenic pathways
Because Gonadorelin directly stimulates the HPG axis, it is frequently utilized in diagnostic stimulation testing to evaluate pituitary responsiveness.
Gonadorelin in Reproductive Endocrine Research
Gonadorelin is utilized in laboratory investigations. In such a context, it has been examined for its effect on hypothalamic-pituitary-gonadal (HPG) axis signaling pathways. Through interaction with GnRH receptors in controlled experimental models, it is studied for its role in modulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion dynamics.
Disclaimer
This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions.
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use
| Form | Peptide, Nasal Spray, Sublingual Tablets |
|---|---|
| Strength | 2mg, 5mg, 10mg, 100mcg/spray=10mg total, 100mcg per tablet/20ct/2mg |
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