Andarine (S-4)

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Andarine (S-4) is a selective androgen receptor modulator (SARM). It is studied in laboratory research for its interaction with androgen receptor signaling pathways.

Additionally, it is a non-steroidal SARM investigated for its receptor-selective binding properties and potential anabolic signaling activity in controlled experimental models.

Chemical Properties

PubChem CID	9824562
Molecular Weight	441.4 g/mol
Molecular Formula	C19H18F3N3O6
IUPAC	(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Chemical Structure 2D
Chemical Structure 3D
CAS	401900-40-1

How does Andarine work?

Andarine S-4 may bind with high affinity to the androgen receptor (AR) ligand-binding domain, forming an AR–ligand complex.

This interaction induces receptor conformational rearrangement that promotes selective recruitment of transcriptional co-activator proteins.

The activated AR complex translocates into the nucleus and binds androgen response elements (AREs) within genomic DNA. This ultimately initiates ligand-dependent transcriptional regulation of genes associated with anabolic cellular pathways and structural tissue remodeling.

Research Applications of Andarine S-4

Andarine S-4 is under investigation. So far, researchers have found the following about the product. Though more research is required for long-term research purposes:

1. Researchers study Andarine S-4 to learn its role in analyzing ligand–receptor interaction kinetics, and androgen receptor conformational change.
2. In preclinical research models, Andarine is studied to investigate androgen receptor–mediated transcription. This includes modulation of intracellular pathways such as PI3K–AKT–mTOR signaling and regulation of gene expression networks.

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