Theacrine

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Theacrine (1,3,7,9-tetramethyluric acid) is a naturally occurring methylxanthine alkaloid found in traditional beverages prepared from Ilex vomitoria (Yaupon holly) and other plant sources. In preclinical and in vitro research models, theacrine has been studied as a purine-based compound with potential mechanisms in adenosine receptor modulation and cellular signaling. Theacrine is structurally related to caffeine but exhibits distinct pharmacological properties in isolated receptor systems. PureRawz supplies pharmaceutical-grade theacrine powder for qualified researchers in receptor pharmacology and purine alkaloid chemistry.

Chemical Properties

Theacrine is a white to off-white crystalline powder with a molecular formula of C₇H₈N₄O₂ and molecular weight of 180.17 g/mol. The compound is sparingly soluble in water and ethanol, and characterized by NMR, MS, and HPLC confirming identity and purity ≥99%. Theacrine is chemically stable under standard storage conditions and does not require specialized handling beyond protection from moisture and light.

Mechanisms Investigated in Preclinical Research

• Adenosine Receptor Antagonism: In vitro receptor binding assays and cell-free systems indicate theacrine exhibits antagonist activity at adenosine receptors (A1, A2A, A2B, A3), with distinct binding profiles compared to caffeine in isolated receptor preparations.
• Purine Signaling Modulation: Preclinical cell culture models suggest theacrine influences purine-dependent signaling pathways including ATP-mediated P2 receptor and adenosine-dependent regulatory mechanisms in isolated cellular systems.

Research Applications

• Adenosine receptor binding kinetics and structure-activity relationship (SAR) studies in cell-free systems
• Radioligand binding assays and competition studies in recombinant receptor preparations
• Cellular cAMP accumulation and second-messenger signaling in isolated cell culture models
• Comparative purine alkaloid pharmacology with caffeine and other methylxanthines
• Metabolic fate and pharmacokinetics in isolated liver enzyme systems (S9 fraction)

Quality Assurance

• Identity: Confirmed by NMR and mass spectrometry
• Purity: ≥99% (HPLC and LC-MS analysis)
• Moisture Content: <0.5% (Karl Fischer titration)
• Microbial Testing: Standard pharmaceutical contamination testing
• Heavy Metals: Tested for Pb, Cd, As, Hg per USP standards
• Stability: Supplied in sealed containers; store at room temperature away from moisture

Why PureRawz

PureRawz sources theacrine from established fine chemical manufacturers with comprehensive analytical protocols. Every batch undergoes third-party purity verification by HPLC and mass spectrometry. We maintain rigorous quality standards to support reproducible receptor pharmacology and alkaloid chemistry research.

Disclaimer: Preclinical and published scientific research indicates potential mechanisms of action for this compound in laboratory and animal models. Any references to published studies are for informational purposes only and do not constitute a claim that this product produces the same effects in humans. The safety and efficacy of this compound in humans have not been established.

ATTENTION: All products sold by PureRawz are intended for laboratory and research purposes only and are not approved for human consumption, veterinary use, or any other use. Products are not evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Customers assume full responsibility for the lawful use of these products in accordance with all applicable federal, state, and local regulations.